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Prediction of Protein Binding Regions in Disordered Proteins
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Many disordered proteins function via binding to a structured partner and undergo a disorder-to-order transition. In order to predict
disordered binding regions, ANCHOR seeks to identify segments that reside in disordered regions, cannot form enough favorable intrachain
interactions to fold on their own and are likely to gain stabilizing energy by interacting with a globular protein partner. The approach relies on
the pairwise energy estimation approach that is the basis for
IUPred, a general disorder prediction method.
To run ANCHOR on multiple sequences you can use
this site.
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References:
Bálint Mészáros,
István Simon and
Zsuzsanna Dosztányi
(2009)
Prediction of Protein Binding Regions in Disordered Proteins
PLoS Comput Biol 5(5): e1000376.
doi:10.1371/journal.pcbi.1000376
Zsuzsanna Dosztányi,
Bálint Mészáros and
István Simon (2009)
ANCHOR: web server for predicting protein
binding regions in disordered proteins
Bioinformatics 25(20): 2745-2746.
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